2014年
1) Hanako Yamaoka, Hideaki Sumiyoshi, Kiyoshi Higashi, Sachie Nakao, Kaori Minakawa, Kayo Sumida, Koichi Saito, Norihiro Ikoma, Tomotaka Mabuchi, Akira Ozawa, and Yutaka Inagaki: A novel small compound accelerates dermal wound healing by modifying infiltration, proliferation and migration of distinct cellular components in mice. J Dermatol Sci 74: 204-213, 2014
2) Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Zamira Hernandez-Nazara,
Ana Rosa Rincon-Sanchez, Yutaka Inagaki, Marcos Rojkind, and M. Raj Lakshman:
Mechanisms of action of acetaldehyde in the up regulation of the human
?2(I) collagen gene in hepatic stellate cells-key roles of Ski, SMAD3,
SMAD4 and SMAD7. Am J Pathol 184: 1458-1467, 2014
3) Isao Okazaki, Takufumi Noro, Eigoro Yamanouchi, Hajime Kuroda, Masayuki
Nakano, Hiroaki Yokomori, and Yutaka Inagaki: Fibrogenesis and Carcinogenesis
in NASH: Role of MMPs and TIMPs. Cancers 6: 1220-1255, 2014
4) 稲垣 豊、住吉秀明：肝臓の線維化とその治療．日本内科学会雑誌 103: 2171-2175, 2014
5) Jun Abe, Shigeyuki Shichino, Satoshi Ueha, Shin-ichi Hashimoto, Michio
Tomura, Yutaka Inagaki, Jens V. Stein, and Kouji Matsushima: Lymph node
stromal cells negatively regulate antigen-specific CD4+ T cell responses.
J Immunol 2014 (in press)
6) Miyako Tanaka, Kenji Ikeda, Takayoshi Suganami, Chikara Komiya, Kozue Ochi, Ibuki Shirakawa, Miho Hamaguchi, Satoshi Nishimura, Ichiro Manabe, Takahisa Matsuda, Kumi Kimura, Hiroshi Inoue, Yutaka Inagaki, Seiichiro Aoe, Sho Yamasaki, and Yoshihiro Ogawa: Macrophage-inducible C-type lectin underlies obesity- induced adipose tissue fibrosis. Nat Commun 2014 (in press)
7) Akihide Kamiya and Yutaka Inagaki: Stem and Progenitor Cell Systems in Liver Development and Regeneration. Hepatol Res 2014 (in press)
8) 稲垣 豊：肝線維化研究の進歩と治療の展望．日本肝臓学会創立50周年記念誌 2014（印刷中）
2013年
1) Tatsuya Tsukui, Satoshi Ueha, Jun Abe, Shin-ichi Hashimoto, Shigeyuki Shichino, Takeshi Shimaoka, Francis HW Shand, Yasuka Arakawa, Kenshiro Oshima, Masahira Hattori, Yutaka Inagaki, Michio Tomura, and Kouji Matsushima: Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis. Am J Pathol 183: 758-773, 2013
2) Xiaoran Li, Ying Bian, Yuri Takizawa, Tomio Hashimoto, Toshiyuki Ikoma, Junzo Tanaka, Naomi Kitamura, Yutaka Inagaki, Masayuki Komada, and Toshiaki Tanaka: ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression. Mol Cancer Res 11: 1437-1447, 2013
2012年
1) Yutaka Inagaki, Reiichi Higashiyama and Kiyoshi Higashi: Novel anti-fibrotic modalities for liver fibrosis: Molecular targeting and regenerative medicine in fibrosis therapy. J Gastroenterol Hepatol 27: 85-88, 2012
2) Yutaka Inagaki and Reiichi Higashiyama: Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis. Hepatol Res 42: 543-548, 2012
3) Isao Okazaki and Yutaka Inagaki: Novel strategies for hepatocellular carcinoma based on MMPs science. Anti-Cancer Agents Med Chem 12: 753-763, 2012
2011年
1) Reiichi Higashiyama, Sachie Nakao, Yayoi Shibusawa, Osamu Ishikawa, Tadashi Moro, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kaori Minakawa, Yasuhiko Tabata, George Bou-Gharios and Yutaka Inagaki: Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice. J Invest Dermatol 131: 529-536, 2011
2) Kiyoshi Higashi, Yoshitaka Tomigahara, Hiroaki Shiraki, Kaori Miyata, Toshiyuki Mikami, Toru Kimura, Tadashi Moro, Yutaka Inagaki, and Hideo Kaneko: A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. J Biol Chem 286: 4485-4492, 2011
2010年
1) Junichi Saito, Yasutada Imamura, Joji Itoh, Shigeo Matsuyama, Akie Maruta, Toshihiko Hayashi, Ataru Sato, Norihito Wada, Kazuo Kashiwazaki, Yutaka Inagaki, Tetsu Watanabe, Yuko Kitagawa and Isao Okazaki: ELISA measurement for urinary 3-hydroxyproline-containing-peptides and its preliminary application to healthy persons and cancer patients. Anticancer Res 30: 1007-1014, 2010
2009年
1) Reiichi Higashiyama, Tadashi Moro, Sachie Nakao, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kazuo Ikeda, Eijiro Adachi, George Bou-Gharios, Isao Okazaki, and Yutaka Inagaki: Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology 137: 1459-1466, 2009
2) Hitoshi Endo, Tetsu Watanabe, Yoshihiko Sugioka, Maki Niioka, Yutaka Inagaki, and Isao Okazaki: Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cell lines. Int J Oncology 35: 1237-1245, 2009
2008年
1) Yutaka Inagaki, Kiyoshi Higashi, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Tadashi Moro, Johbu Itoh, Toshiyuki Mikami, Toru Kimura, Goshi Shiota, Ichiro Kuwabara, and Isao Okazaki: Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7. Gastroenterology 134: 1180-1190, 2008
2) Tadashi Moro, Yoshihito Shimoyama, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Yoshihiko Sugioka, Hideo Inoue, Isao Okazaki, and Yutaka Inagaki: Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis. Life Sciences 83: 531-539, 2008
2007年
1) Reiichi Higashiyama, Yutaka Inagaki, Yun Yu Hong, Miwa Kushida, Sachie Nakao, Maki Niioka, Tetsu Watanabe, Hideyuki Okano, Yumi Matsuzaki, Goshi Shiota and Isao Okazaki: Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 45: 213-222, 2007
2) Kohji Kinoshita, Yuji Iimuro, Jiro Fujimoto, Yutaka Inagaki, Kazuhiko
Namikawa, Hiroshi Kiyama, Yuji Nakajima, Kohji Otogawa, Norifumi Kawada,
Scott L Friedman and Kazuo Ikeda: Targeted and regulable expression of
transgenes in hepatic stellate cells and myofibroblasts in culture and
in vivo using an adenoviral Cre-LoxP system to antagonise hepatic fibrosis.
Gut 56: 396-404, 2007
3) Kohji Kinoshita, Yuji Iimuro, Kohji Otogawa, Shizuya Saika, Yutaka Inagaki, Yuji Nakajima, Norifumi Kawada, Scott L Friedman and Kazuo Ikeda: Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut 56: 706-714, 2007
4) Yutaka Inagaki, Reiichi Higashiyama and Isao Okazaki: Treatment Strategy
for liver fibrosis through recruitment and differentiation of bone marrow
stem/progenitor cells. Hepatol Res 37: 991-993, 2007
5) Yutaka Inagaki and Isao Okazaki: Emerging insights into transforming
growth factor-? Smad signal in hepatic fibrogenesis. Gut 56: 284-292, 2007
2006年
1) Nobuhiro Izumi, Shinjiro Mizuguchi, Yutaka Inagaki, Shizuya Saika, Norifumi Kawada, Yuji Nakajima, Kiyotoshi Inoue, Shigefumi Suehiro, Scott L Friedman and Kazuo Ikeda: BMP-7 opposes TGF??-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. Am J Physiol Lung Cellular and Molecular Physiology 290: L120-L126, 2006
2) Youko Komaki, Hiroyuki Furuya, Reiichi Higashiyama, Takaaki Kinoue, Shun Ito, Yutaka Inagaki, Tetsu Watanabe, Yasuhiko Honma, and Isao Okazaki. Detection of individual over-smoking using conventional laboratory tests. Tokai J Exp Clin Med 31: 17-28, 2006
2005年
1) Sonoko Chujo, Fumiaki Shirasaki, Shigeru Kawara, Yutaka Inagaki, Takuro Kinbara, Masaharu Takigawa, and Kazuhiko Takehara: Connective tissue growth factor causes persistent pro?2(I) collagen gene expression induced by transforming growth factor-? in a mouse fibrosis model. J Cell Physiol 203: 447-456, 2005
2) Tomoaki Yoshino, Hideaki Sumiyoshi, Toshitaka Shin, Noritaka Matsuo,
Yutaka Inagaki, Yoshifumi Ninomiya and Hidekatsu Yoshioka: Multiple proteins
are involved in the protein-DNA complex in the proximal promoter of the
human ?1(III) collagen gene (COL3A1). Biochim Biophys Acta 1729: 94-104,
2005
3) Yutaka Inagaki, Miwa Kushida, Kiyoshi Higashi, Johbu Itoh, Reiichi Higashiyama,
Yun Yu Hong, Norifumi Kawada, Kazuhiko Namikawa, Hiroshi Kiyama, George
Bou-Gharios, Tetsu Watanabe, Isao Okazaki and Kazuo Ikeda: Cell type-specific
intervention of TGF-?/Smad signaling suppresses collagen gene expression
and hepatic fibrosis in mice. Gastroenterology 129: 259-268, 2005
4) Gianluca Svegliati-Baroni, Yutaka Inagaki, Ana-Rosa Rincon-Sanchez,
Cindy Else, Stefania Saccomanno, Antonio Benedetti, Francesco Ramirez and
Marcos Rojkind: Early response of ?2(I) collagen to acetaldehyde in human
hepatic stellate cells is TGF-?-independent. Hepatology 42: 343-352, 2005
2004年
1) Yoshihiko Sugioka, Tetsu Watanabe, Yutaka Inagaki, Miwa Kushida, Maki Niioka, Hitoshi Endo, Reiichi Higashiyama and Isao Okazaki: c-JUN NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. Int J Cancer 109: 867-874, 2004
2003年
1) Kiyoshi Higashi, Yutaka Inagaki, Noriyuki Suzuki, Shinichi Mitsui, Alain Mauviel, Hideo Kaneko and Iwao Nakatsuka: Y-box binding protein YB-1 mediates transcriptional repression of human ?2(I) collagen gene expression by interferon-?. J Biol Chem 278: 5156-5162, 2003
2) Yutaka Inagaki, Tomoyuki Nemoto, Miwa Kushida, Yin Sheng, Kiyoshi Higashi,
Kazuo Ikeda, Norifumi Kawada, Fumiaki Shirasaki, Kazuhiko Takehara, Kota
Sugiyama, Mitsukiyo Fujii, Hiroshi Yamauchi, Atsuhito Nakao, Benoit de
Crombrugghe, Tetsu Watanabe and Isao Okazaki: Interferon ? down-regulates
collagen gene transcription and suppresses experimental hepatic fibrosis
in mice. Hepatology 38: 890-899, 2003
3) Kiyoshi Higashi, Yutaka Inagaki, Ko Fujimori, Atsuhito Nakao, Hideo Kaneko and Iwao Nakatsuka: Interferon-? interferes with transforming growth factor-? signaling through direct interaction of YB-1 with Smad3. J Biol Chem 278: 43470-43479, 2003
4) Yutaka Kanamaru, Atsuhito Nakao, Yuichi Tanaka, Yutaka Inagaki, Hiroko
Ushio, Isao Shirato, Satoshi Horikoshi, Ko Okumura, Hideoki Ogawa and Yasuhiko
Tomino: Involvement of p300 in TGF-?/Smad-pathway-mediated ?2(I) collagen
expression in mouse mesangial cells. Nephron Exp Nephrol 95: e36-e42, 2003
5) Yutaka Inagaki, Kiyoshi Higashi, Tomoyuki Nemoto, Miwa Kushida and Isao
Okazaki: Treatment strategies for organ fibrosis based on regulation of
collagen metabolism. Connective Tissue 35: 193-200, 2003
6) Yutaka Inagaki, Tomoyuki Nemoto, and Atsuhito Nakao: Transcriptional activation of type I collagen gene during hepatic fibrogenesis. In: Extracellular Matrix and the Liver-Approach to Gene Therapy, Okazaki I, Ninomiya Y, Friedman SL and Tanikawa K (Eds), Academic Press, New York, 2003, p.233-248.
2002年
1) 岡崎 勲，渡辺 哲，稲垣 豊：肝線維化研究の進歩．日本消化器病学会雑誌 99: 353-364, 2002
2) Yutaka Inagaki, Tomoyuki Nemoto, and Atsuhito Nakao: Transcriptional
regulation of type I collagen gene expression by transforming growth factor-?/Smad
signaling and its antagonistic factors. Connective Tissue 34: 139-146,
2002
2002年（東海大学着任）以前の主要論文
1) Yutaka Inagaki, Sharada Truter and Francesco Ramirez: Transforming growth factor-? stimulates ?2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 269: 14828- 14834, 1994
2) Yutaka Inagaki, Sharada Truter, Maurizio DiLiberto, Shizuko Tanaka and
Francesco Ramirez: Overlapping pathways mediate the opposing actions of
tumor necrosis factor-? and transforming growth factor-? on ?2(I) collagen
gene transcription. J Biol Chem 270: 3353-3358, 1995
3) Yutaka Inagaki, Sharada Truter, Patricia Greenwel, Marcos Rojkind, Masashi Unoura, Kenichi Kobayashi and Francesco Ramirez: Regulation of the ?2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology 22: 573-579, 1995
4) Patricia Greenwel, Yutaka Inagaki, Wei Hu, Martin Walsh and Francesco Ramirez: Sp1 is required for the early response of ?2(I) collagen to transforming growth factor-?1. J Biol Chem 272: 19738-19745, 1997
5) Yutaka Inagaki, Sharada Truter, George Bou-Gharios, Lee Ann Garrett,
Benoit de Crombrugghe, Tomoyuki Nemoto and Patricia Greenwel: Activation
of pro?2(I) collagen promoter during hepatic fibrogenesis in transgenic
mice. Biochem Biophys Res Commun 250: 606-611, 1998
6) Wen Zhang, Jiongwen Ou, Yutaka Inagaki, Patricia Greenwel and Francesco
Ramirez: Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming
growth factor ?1 stimulation of ?2(I) collagen (COL1A2) transcription.
J Biol Chem 275: 39237-39245, 2000
7) Yutaka Inagaki, Mizuko Mamura, Yutaka Kanamaru, Patricia Greenwel, Tomoyuki
Nemoto, Kazuhiko Takehara, Peter ten Dijke and Atsuhito Nakao: Constitutive
phosphorylation and nuclear localization of Smad3 are correlated with increased
collagen gene transcription in activated hepatic stellate cells. J Cell
Physiol 187: 117-123, 2001
8) Yutaka Inagaki, Tomoyuki Nemoto, Atsuhito Nakao, Peter ten Dijke, Kenichi Kobayashi, Kazuhiko Takehara and Patricia Greenwel: Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific ?2(I) collagen gene transcription. J Biol Chem 276: 16573-16579, 2001