5)Shigeyuki Shichino, Jun Abe, Satoshi Ueha, Mikiya Otsuji, Tatsuya Tsukui, Mizuha Kosugi-Kanaya, Francis HW Shand, Shin-ichi Hashimoto, Hiroshi I. Suzuki, Teppei Morikawa, Yutaka Inagaki, and Kouji Matsushima: Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice. Am J Pathol 185: 2923-2938, 2015
6)Tatsuya Tsukui, Satoshi Ueha, Shigeyuki Shichino, Yutaka Inagaki, and Kouji Matsushima: Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis. Am J Pathol 185: 2939-2948, 2015
7)Jin Imai, Katsuto Hozumi, Hideaki Sumiyoshi, Masaki Yazawa, Ken-ichi Hirano, Jun Abe, Kiyoshi Higashi, Yutaka Inagaki, and Tetsuya Mine: Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis. Biochem Biophys Res Commun 468: 554-60, 2015
8)Tadashi Moro, Sachie Nakao, Hideaki Sumiyoshi, Takamasa Ishii, Masaki Miyazawa, Naoaki Ishii, Tadayuki Sato, Yumi Iida, Yoshinori Okada, Masayuki Tanaka, Hideki Hayashi, Satoshi Ueha, Kouji Matsushima, and Yutaka Inagaki: A combination of mitochondrial oxidative stress and excess fat/calorie intake accelerates steatohepatitis by enhancing hepatic CC chemokine production in mice. PLoS ONE 11: e0146592, 2016
9)Yusuke Matsuo, Fumitaka Mizoguchi, Tetsuya Saito, Kimito Kawahata, Satoshi Ueha, Kouji Matsushima, Yutaka Inagaki, Nobuyuki Miyasaka, and Hitoshi Kohsaka: Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis. Biochem Biophys Res Commun 2016 (in press)
10)Ah-Mee Park, Kyosuke Kanai, Tatsuki Itoh, Takao Sato, Tatsuya Tsukui, Yutaka Inagaki, Moises Selman, Kouji Matsushima, Osamu Yoshie:
Heat shock protein 27 plays a pivotal role in myofibroblast differentiation and in the development of bleomycin-induced pulmonary fibrosis. PLoS ONE 2016 (in press)
2014年
1) Hanako Yamaoka, Hideaki Sumiyoshi, Kiyoshi Higashi, Sachie Nakao, Kaori Minakawa, Kayo Sumida, Koichi Saito, Norihiro Ikoma, Tomotaka Mabuchi, Akira Ozawa, and Yutaka Inagaki: A novel small compound accelerates dermal wound healing by modifying infiltration, proliferation and migration of distinct cellular components in mice. J Dermatol Sci 74: 204-213, 2014
2) Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Zamira Hernandez-Nazara, Ana Rosa Rincon-Sanchez, Yutaka Inagaki, Marcos Rojkind, and M. Raj Lakshman: Mechanisms of action of acetaldehyde in the up regulation of the human α-2(I) collagen gene in hepatic stellate cells-key roles of Ski, SMAD3, SMAD4 and SMAD7. Am J Pathol 184: 1458-1467, 2014
3) Isao Okazaki, Takufumi Noro, Eigoro Yamanouchi, Hajime Kuroda, Masayuki Nakano, Hiroaki Yokomori, and Yutaka Inagaki: Fibrogenesis and Carcinogenesis in NASH: Role of MMPs and TIMPs. Cancers 6: 1220-1255, 2014
1) Tatsuya Tsukui, Satoshi Ueha, Jun Abe, Shin-ichi Hashimoto, Shigeyuki Shichino, Takeshi Shimaoka, Francis HW Shand, Yasuka Arakawa, Kenshiro Oshima, Masahira Hattori, Yutaka Inagaki, Michio Tomura, and Kouji Matsushima: Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis. Am J Pathol 183: 758-773, 2013
2) Xiaoran Li, Ying Bian, Yuri Takizawa, Tomio Hashimoto, Toshiyuki Ikoma, Junzo Tanaka, Naomi Kitamura, Yutaka Inagaki, Masayuki Komada, and Toshiaki Tanaka: ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression. Mol Cancer Res 11: 1437-1447, 2013
2012年
1) Yutaka Inagaki, Reiichi Higashiyama and Kiyoshi Higashi: Novel anti-fibrotic modalities for liver fibrosis: Molecular targeting and regenerative medicine in fibrosis therapy. J Gastroenterol Hepatol 27: 85-88, 2012
2) Yutaka Inagaki and Reiichi Higashiyama: Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis. Hepatol Res 42: 543-548, 2012
3) Isao Okazaki and Yutaka Inagaki: Novel strategies for hepatocellular carcinoma based on MMPs science. Anti-Cancer Agents Med Chem 12: 753-763, 2012
2011年
1) Reiichi Higashiyama, Sachie Nakao, Yayoi Shibusawa, Osamu Ishikawa, Tadashi Moro, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kaori Minakawa, Yasuhiko Tabata, George Bou-Gharios and Yutaka Inagaki: Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice. J Invest Dermatol 131: 529-536, 2011
2) Kiyoshi Higashi, Yoshitaka Tomigahara, Hiroaki Shiraki, Kaori Miyata, Toshiyuki Mikami, Toru Kimura, Tadashi Moro, Yutaka Inagaki, and Hideo Kaneko: A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. J Biol Chem 286: 4485-4492, 2011
2010年
1) Junichi Saito, Yasutada Imamura, Joji Itoh, Shigeo Matsuyama, Akie Maruta, Toshihiko Hayashi, Ataru Sato, Norihito Wada, Kazuo Kashiwazaki, Yutaka Inagaki, Tetsu Watanabe, Yuko Kitagawa and Isao Okazaki: ELISA measurement for urinary 3-hydroxyproline-containing-peptides and its preliminary application to healthy persons and cancer patients. Anticancer Res 30: 1007-1014, 2010
2009年
1) Reiichi Higashiyama, Tadashi Moro, Sachie Nakao, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kazuo Ikeda, Eijiro Adachi, George Bou-Gharios, Isao Okazaki, and Yutaka Inagaki: Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology 137: 1459-1466, 2009
2) Hitoshi Endo, Tetsu Watanabe, Yoshihiko Sugioka, Maki Niioka, Yutaka Inagaki, and Isao Okazaki: Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cell lines. Int J Oncology 35: 1237-1245, 2009
2008年
1) Yutaka Inagaki, Kiyoshi Higashi, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Tadashi Moro, Johbu Itoh, Toshiyuki Mikami, Toru Kimura, Goshi Shiota, Ichiro Kuwabara, and Isao Okazaki: Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7. Gastroenterology 134: 1180-1190, 2008
2) Tadashi Moro, Yoshihito Shimoyama, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Yoshihiko Sugioka, Hideo Inoue, Isao Okazaki, and Yutaka Inagaki: Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis. Life Sciences 83: 531-539, 2008
2007年
1) Reiichi Higashiyama, Yutaka Inagaki, Yun Yu Hong, Miwa Kushida, Sachie Nakao, Maki Niioka, Tetsu Watanabe, Hideyuki Okano, Yumi Matsuzaki, Goshi Shiota and Isao Okazaki: Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 45: 213-222, 2007
2) Kohji Kinoshita, Yuji Iimuro, Jiro Fujimoto, Yutaka Inagaki, Kazuhiko Namikawa, Hiroshi Kiyama, Yuji Nakajima, Kohji Otogawa, Norifumi Kawada, Scott L Friedman and Kazuo Ikeda: Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre-LoxP system to antagonise hepatic fibrosis. Gut 56: 396-404, 2007
3) Kohji Kinoshita, Yuji Iimuro, Kohji Otogawa, Shizuya Saika, Yutaka Inagaki, Yuji Nakajima, Norifumi Kawada, Scott L Friedman and Kazuo Ikeda: Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut 56: 706-714, 2007
4) Yutaka Inagaki, Reiichi Higashiyama and Isao Okazaki: Treatment Strategy for liver fibrosis through recruitment and differentiation of bone marrow stem/progenitor cells. Hepatol Res 37: 991-993, 2007
5) Yutaka Inagaki and Isao Okazaki: Emerging insights into transforming growth factor-β Smad signal in hepatic fibrogenesis. Gut 56: 284-292, 2007
2006年
1) Nobuhiro Izumi, Shinjiro Mizuguchi, Yutaka Inagaki, Shizuya Saika, Norifumi Kawada, Yuji Nakajima, Kiyotoshi Inoue, Shigefumi Suehiro, Scott L Friedman and Kazuo Ikeda: BMP-7 opposes TGFβ1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. Am J Physiol Lung Cellular and Molecular Physiology 290: L120-L126, 2006
2) Youko Komaki, Hiroyuki Furuya, Reiichi Higashiyama, Takaaki Kinoue, Shun Ito, Yutaka Inagaki, Tetsu Watanabe, Yasuhiko Honma, and Isao Okazaki. Detection of individual over-smoking using conventional laboratory tests. Tokai J Exp Clin Med 31: 17-28, 2006
2) Tomoaki Yoshino, Hideaki Sumiyoshi, Toshitaka Shin, Noritaka Matsuo, Yutaka Inagaki, Yoshifumi Ninomiya and Hidekatsu Yoshioka: Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human α1(III) collagen gene (COL3A1). Biochim Biophys Acta 1729: 94-104, 2005
3) Yutaka Inagaki, Miwa Kushida, Kiyoshi Higashi, Johbu Itoh, Reiichi Higashiyama, Yun Yu Hong, Norifumi Kawada, Kazuhiko Namikawa, Hiroshi Kiyama, George Bou-Gharios, Tetsu Watanabe, Isao Okazaki and Kazuo Ikeda: Cell type-specific intervention of TGF-β/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. Gastroenterology 129: 259-268, 2005
4) Gianluca Svegliati-Baroni, Yutaka Inagaki, Ana-Rosa Rincon-Sanchez, Cindy Else, Stefania Saccomanno, Antonio Benedetti, Francesco Ramirez and Marcos Rojkind: Early response of α2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-β-independent. Hepatology 42: 343-352, 2005
2004年
1) Yoshihiko Sugioka, Tetsu Watanabe, Yutaka Inagaki, Miwa Kushida, Maki Niioka, Hitoshi Endo, Reiichi Higashiyama and Isao Okazaki: c-JUN NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. Int J Cancer 109: 867-874, 2004
2003年
1) Kiyoshi Higashi, Yutaka Inagaki, Noriyuki Suzuki, Shinichi Mitsui, Alain Mauviel, Hideo Kaneko and Iwao Nakatsuka: Y-box binding protein YB-1 mediates transcriptional repression of humanα 2(I) collagen gene expression by interferon-γ. J Biol Chem 278: 5156-5162, 2003
3) Kiyoshi Higashi, Yutaka Inagaki, Ko Fujimori, Atsuhito Nakao, Hideo Kaneko and Iwao Nakatsuka: Interferon-γ interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3. J Biol Chem 278: 43470-43479, 2003
4) Yutaka Kanamaru, Atsuhito Nakao, Yuichi Tanaka, Yutaka Inagaki, Hiroko Ushio, Isao Shirato, Satoshi Horikoshi, Ko Okumura, Hideoki Ogawa and Yasuhiko Tomino: Involvement of p300 in TGF-β/Smad-pathway-mediated α2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol 95: e36-e42, 2003
5) Yutaka Inagaki, Kiyoshi Higashi, Tomoyuki Nemoto, Miwa Kushida and Isao Okazaki: Treatment strategies for organ fibrosis based on regulation of collagen metabolism. Connective Tissue 35: 193-200, 2003
6) Yutaka Inagaki, Tomoyuki Nemoto, and Atsuhito Nakao: Transcriptional activation of type I collagen gene during hepatic fibrogenesis. In: Extracellular Matrix and the Liver-Approach to Gene Therapy, Okazaki I, Ninomiya Y, Friedman SL and Tanikawa K (Eds), Academic Press, New York, 2003, p.233-248.
2) Yutaka Inagaki, Tomoyuki Nemoto, and Atsuhito Nakao: Transcriptional regulation of type I collagen gene expression by transforming growth factor-β/Smad signaling and its antagonistic factors. Connective Tissue 34: 139-146, 2002
2002年 （東海大学着任）以前の主要論文
1) Yutaka Inagaki, Sharada Truter and Francesco Ramirez: Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 269: 14828- 14834, 1994
2) Yutaka Inagaki, Sharada Truter, Maurizio DiLiberto, Shizuko Tanaka and Francesco Ramirez: Overlapping pathways mediate the opposing actions of tumor necrosis factor-β and transforming growth factor-β on α2(I) collagen gene transcription. J Biol Chem 270: 3353-3358, 1995
3) Yutaka Inagaki, Sharada Truter, Patricia Greenwel, Marcos Rojkind, Masashi Unoura, Kenichi Kobayashi and Francesco Ramirez: Regulation of the α2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology 22: 573-579, 1995
4) Patricia Greenwel, Yutaka Inagaki, Wei Hu, Martin Walsh and Francesco Ramirez: Sp1 is required for the early response of α2(I) collagen to transforming growth factor-β1. J Biol Chem 272: 19738-19745, 1997
5) Yutaka Inagaki, Sharada Truter, George Bou-Gharios, Lee Ann Garrett, Benoit de Crombrugghe, Tomoyuki Nemoto and Patricia Greenwel: Activation of proα2(I) collagen promoter during hepatic fibrogenesis in transgenic mice. Biochem Biophys Res Commun 250: 606-611, 1998
6) Wen Zhang, Jiongwen Ou, Yutaka Inagaki, Patricia Greenwel and Francesco Ramirez: Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor β1 stimulation of α2(I) collagen (COL1A2) transcription. J Biol Chem 275: 39237-39245, 2000
7) Yutaka Inagaki, Mizuko Mamura, Yutaka Kanamaru, Patricia Greenwel, Tomoyuki Nemoto, Kazuhiko Takehara, Peter ten Dijke and Atsuhito Nakao: Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 187: 117-123, 2001
8) Yutaka Inagaki, Tomoyuki Nemoto, Atsuhito Nakao, Peter ten Dijke, Kenichi
Kobayashi, Kazuhiko Takehara and Patricia Greenwel: Interaction between
GC box binding factors and Smad proteins modulates cell lineage-specific
α2(I) collagen gene transcription. J Biol Chem 276: 16573-16579, 2001