研究業績

2023年

1) Hirotaka Iura, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Masatake Tanaka, Kazuhiro Hata, Tetsuya Tamaru, Yohei Haruta, Gentaro Ono, Kazuki Kitade, Ken Kijima, Kensuke Kubota, Yutaka Inagaki, Masato Ohtsuka, Ken Okazaki, Koji Murakami, Shusaku Matsuda, Masami Tokunaga, Takaaki Yoshimoto, Takeshi Maeda, Yasuharu Nakashima, Seiji Okada. Bone marrow-derived fibroblast migration via Periostin causes irreversible arthrogenic contracture after joint immobilization. FASEB J 37: e22842, 2023
DOI:10.1096/fj.202201598R

2022年

1) Yasuhiro Nakano, Sachie Nakao, Minako Sueoka, Daigo Kasahara, Yuri Tanno, Hideaki Sumiyoshi, Tohru Itoh, Atsushi Miyajima, Katsuto Hozumi, Yutaka Inagaki. Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice. Commun Biol 5: 85, 2022
DOI:10.1038/s42003-022-03013-8

2）Toshiaki Tanaka, Koji Moriya, Makoto Tsunenaga, Takayo Yanagawa, Hiromi Morita, Takashi Minowa, Yoh-ichi Tagawa, Nobutaka Hanagata, Yutaka Inagaki, Toshiyuki Ikoma. Visualized procollagen I α1 demonstrates the intracellular processing of prpeptide. Life Sci Alliance 5: e202101060, 2022
DOI:10.26508/lsa.202101060

3）Hidehiko Yagasaki, Susumu Takekoshi, Kanae Kitatani, Chikara Kato, Hiroyuki Yamazaki, Kie Shoyama, Takaaki Tsuboi, Tomohiko Matsuzaki, Yutaka Inagaki, Ryota Masuda, Masayuki Iwazaki. Protective effect of ebselen on bleomycin-induced lung fibrosis: Analysis of the molecular mechanism of lung fibrosis mediated by oxidative stress. Free Radical Research 56: 473-482, 2022
DOI:10.1080/10715762.2022.2092477

2021年

1) Hiroshi Kawano, Kazuya Koyama, Nobuhito Naito, Yuko Toyoda, Kozo Kagawa, Naoki Takahashi, Seidai Sato, Haruka Nishimura, Yuya Yamashita, Hisatsugu Goto, Yutaka Inagaki, Yasuhiko Nishioka. Development of improved method to identify and analyze lung fibrocytes with flow cytometry in a reporter mouse strain. Immun Inflamm Dis 9:120-127,2021

DOI:10.1002/iid3.361

2) Yosuke Kurashima, Takaaki Kigoshi, Sayuri Murasaki, Fujimi Arai, Kaoru Shimada, Natsumi Seki, Yun-Gi Kim, Koji Hase, Hiroshi Ohno, Kazuya Kawano, Hiroshi Ashida, Toshihiko Suzuki, Masako Morimoto, Yukari Saito, Ai Sasou, Yuki Goda, Yoshikazu Yuki, Yutaka Inagaki, Hideki Iijima, Wataru Suda, Masahira Hattori, Hiroshi Kiyono. Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. Nat Commun 12: 1067, 2021
DOI:10.1038/s41467-021-21277-21

3）Hideaki Sumiyoshi, Yousuke Okamura, Akira T. Kawaguchi, Tomoko Kubota, Hitoshi Endo, Takayo Yanagawa, Junpei Yasuda, Yuki Matsuki, Sachie Nakao, Yutaka Inagaki. External administration of moon jellyfish collagen solution accelerates physiological wound healing and improves delayed wound closure in diabetic model mice. Regenerative Therapy 18: 223-230, 2021
DOI:10.1016/j.reth.2021.06.008

4) Kazuya Anzai, Kota Tsuruya, Kinuyo Ida, Tatehiro Kagawa, Yutaka Inagaki, Akihide Kamiya. Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts. Sci Rep 11: 18551, 2021 DOI:10.1038/s41598-021-97937-6.

5) Masatoshi Kakizaki, Yuichiro Yamamoto, Shunya Nakayama, Kazuaki Kameda, Etsuko Nagashima, Masatoshi Ito, Takashi Suyama, Yumi Matsuzaki, Tetsuhiro Chiba, Hideaki Sumiyoshi, Yutaka Inagaki, Ai kotani. Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice. Cell Death Dis 12: 1010, 2021.
DOI:10.1038/s41419-021-04204-7

6) Yuki Matsuki, Takayo Yanagawa, Hideaki Sumiyoshi, Jumpei Yasuda, Sachie Nakao, Mitsuaki Goto, Teiko Shibata-Seki, Toshihiro Akaike, Yutaka Inagaki. Modification of exosomes with carbonate apatite and a glycan polymer improves transduction efficiency and target cell selectivity. Biochem Biophys Res Commun 583: 93-99、2021
DOI:10.1016/j.bbrc.2021.10.063

7) Yukari Shida, Hitoshi Endo, Satoshi Owada, Yutaka Inagaki, Hideaki Sumiyoshi, Akihide Kamiya, Tomoo Eto, Masayuki Tatemichi. Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats. Sci Rep 11:23104, 2021
DOI:10.1038/s41598-021-02591-7

2020年

1) Yasuhiro Nakano, Akihide Kamiya, Hideaki Sumiyoshi, Kota Tsuruya, Tatehiro Kagawa, Yutaka Inagaki: A deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice. Hepatology 71:1437-1452, 2020

DOI:10.1002/hep.30965

2) Jin Imai, Takashi Yahata, Hitoshi Ichikawa, Abd Aziz Ibrahim, Masaki Yazawa, Hideaki Sumiyoshi, Yutaka Inagaki, Masashi Matsushima, Takayoshi Suzuki, Tetsuya Mine, Kiyoshi Ando, Toshio Miyata, Katsuto Hozumi: Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice. Intestinal Res 18:219-228,2020
DOI:10.5217/ir.2019.00037

3) Hideaki Sumiyoshi, Sachie Nakao, Hitoshi Endo, Takayo Yanagawa, Yasuhiro Nakano, Yosuke Okamura, Akira T. Kawaguchi, Yutaka Inagaki: A novel composite biomaterial made of jellyfish and porcine collagens accelerates dermal wound healing by enhancing reepithelization and granulation tissue formation in mice. Adv Wound Care 9: 295-311, 2020

DOI:10.1089/wound.2019.1014

4) Hiromi Chikada, Kinuyo Ida, Yuji Nishikawa, Yutaka Inagaki, Akihide Kamiya: Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice. Sci Rep 10:9704, 2020

DOI:10.1038/s41598-020-66539-z

5) Daigo Kasahara, Hideaki Sumiyoshi, Hitoshi Endo, Takayo Yanagawa, Yasuhiro Nakano, Yuki Matsuki, Sachie Nakao, Akihide Kamiya, Hiroshi Kimura, Yutaka Inagaki:Visualization and isolation of zone-specific murine hepatocytes that maintain distinct cytochrome P450 oxidase expression in primary culture. Biochem Biophys Res Commun 528:420-425, 2020

DOI:10.1016/j.bbrc.2020.05.202

6) Hitoshi Endo, Satoshi Owada, Yutaka Inagaki, Yukari Shida, Masayuki Tatemichi: Metabolic reprogamming sustains cancer cell survival following extracellular matrix detachment. Redox Biol 36: 101643, 2020
DOI:10.1016/j.redox.2020.101643

7) Isao Okazaki,Shinsuke Shibata,Wataru Ando, Takayo Yanagawa, HIroaki Yokomori, Akira Sonoda, Norihiko Suzuki,Eigoro Yamanouchi, Shinya Okada, Shinichi kamimura, Kazuaki Hachimura, Takashi Takaki, Katsuya Otori, Yutaka Suzuki, Hideyuki Okano, Yutaka Inagaki:Sequental matrix metalloproteinase-1 expression triggered by infiltrating monocytic lineage cells modulates pathophysiological aspects of human nonalcoholic steatohepatitis. Metalloproteinases Med7:1-13,2020

DOI:10.2147/MNM.S252991

8) Seiichi Matsumura, Yosuke Kurashima, Sayuri Murasaki, Masako Morimoto, Fujimi Arai, Yukari Saito, Nana Katayama, Dayoung Kim, Yutaka Inagaki, Takahiro Kudo, Peter B. Ernst, Toshiaki Shimizu, Hiroshi Kiyono. Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation. Sci Rep 10:18351, 2020
DOI:10.1038/s41598-020-75186-3

2019年

1) Takayo Yanagawa, Hideaki Sumiyoshi, Kiyoshi Higashi, Sachie Nakao, Reiichi Higashiyama, Hiroshi Fukumitsu, Kaori Minakawa, Yosuke Chiba, Yuhei Suzuki, Kayo Sumida, Koichi Saito, Akihide Kamiya, Yutaka Inagaki: Identification of a novel bone marrow cell-derived accelerator of fibrotic liver regeneration through mobilization of hepatic progenitor cells in mice. Stem Cells 37：89-101,2019
DOI:10.1002/stem.2916

2) Shigeyuki Shichino, Satoshi Ueha, Shin-ichi Hashimoto, Mikiya Otsuji, Jun Abe, Tatsuya Tsukui, Shungo Deshimaru, Takumi Nakajima, Mizuha Kosugi-Kanaya, Francis HW Shand, Yutaka Inagaki, HItoshi Shimano, Kouji Matsushima:Transcriptome network analysis identifies protective role of the LXR-SREBP-1c axis in murine pulmonary fibrosis. JCI Insight 4: e122163, 2019 DOI:10.1172/jci.insight.122163

3) Tatsuya Tsukui, Satoshi Ueha, Shigeyuki Shichino, Shin-ichi Hashimoto, Takumi Nakajima, Shiraishi K, Kihara M, Kiyonari H, Yutaka Inagaki, Kouji Matsushima: Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis. Biochem Biophys Res Commun 514: 684-690, 2019
DOI:10.1016/j.bbrc.2019.05.011

4) Yosuke Kurashima, Daisuke Tokuhara, Mariko Kamioka, Yutaka Inagaki, Hiroshi Kiyono: Intrinsic control of surface immune and epithelial homeostasis by tissue-resident gut stromal cells. Front Immunol 10: 1281, 2019
DOI:10.3389/fimmu.2019.01281DOI:10.1172/jci.insight.122163

5) Tomomi Ichikawa, Kiyoshi Hirahara, Kota Kokubo, Masahiro Kiuchi, Ami Aoki , Yuki Morimoto, Jin Kumagai, Atsushi Onodera, Naoko Mato, Damon J. Tumes, Yoshiyuki Goto, Koichi Hagiwara, Yutaka Inagaki, Tim Sparwasser, Kazuyuki Tobe, Toshinori Nakayama: CD103^hi T_reg cells constrain lung fibrosis induced by CD103^low tissue-resident pathogenic CD4 T cells. Nat Immunol 20: 1469-1480, 2019
DOI:10.1038/s41590-019-0494-y

6) Masahiro Asakawa, Michiko Itoh, Takayoshi Suganami, Takeru Sakai, Sayaka Kanai, Ibuki Shirakawa, Xunmei Yuan, Tomomi Hatayama, Shu Shimada, Yoshimitsu Akiyama, Katsuhito Fujiu, Yutaka Inagaki, Ichiro Manabe, Shoji Yamaoka, Tetsuya Yamada, Shinji Tanaka, Yoshihiro Ogawa: Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis. Sci Rep 9:19601, 2019
DOI:10.1038/s41598-019-56039-0

2018年

1) Wataru Ando, Hiroaki Yokomori, Nobuhiro Tsutsui, Eigoro Yamanouchi, Yutaka Suzuki, Masaya Oda, Yutaka Inagaki, Katsuya Otori, and Isao Okazaki: Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis. Clin Mol Hepatol 24:61-76,2018
DOI:10.3350/cmh.2017.0030

2) Juanjuan Zhao, Yasuo Okamoto, Yuya Asano, Kazuhiro Ishimaru, Sho Aki, Kazuaki Yoshioka, Noriko Takuwa, Takashi Wada, Yutaka Inagaki, Chiaki 　Takahashi, Takumi Nishiuchi, Yoh Takuwa: Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages. PLoS ONE 13: e0197604, 2018 DOI:10.1371/journal.pone.0197604

3) Hiromi Chikada, Kinuyo Ida , Emi Ando , Yutaka Inagaki , Akemi Sakamoto, Akihide Kamiya: Establishment and analyses of a mouse model that regulates sex-related differences in drug metabolism in the liver. Lab Invest 98: 1500-1511, 2018
DOI:10.1038/s41341-018-0088

4) Hitoshi Endo, Satoshi Owada, Yutaka Inagaki, Yukari Shida, Masayuki Tatemichi: Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells. Sci Rep 8: 10122, 2018

DOI:10.1038/s41598-108-28074-w

5) Akihide Kamiya, Hiromi Chikada, Kinuyo Ida, Emi Ando, KotaTsuruya, Tatehiro Kagawa, Yutaka Inagaki: An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells. Stem Cell Res 32: 17-24, 2018
DOI: 10.1016/j.scr.2018.08.018

6) Kunihiko Souma, Shigeyuki Shichino , Shinichi Hashimoto, Satoshi Ueha, Tatsuya Tsukui, Takuya Nakajima, Hiroshi Suzuki, Francis Shand, Yutaka Inagaki, Takahide Nagase, Kouji Matsushima: Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis. Sci Rep 8: 16642, 2018
DOI:10.1038/s41598-018-34839-0

2017年

1) Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, and Yutaka Inagaki: Identification of a novel alpha-fetoprotein-expressing cell population induced by Jagged1/Notch2 signal in murine fibrotic liver. Hepatol Commun 1: 215-229, 2017

DOI:10.1002/hep4.1026

2) Rolen M. Quadros, Hiromi Miura, Donald W. Harms, Hisako Akatsuka, Takehito Sato, Tomomi Aida, Ronald Redder, Guy P. Richardson, Yutaka Inagaki, Daisuke Sakai, Shannon M. Buckley, Parthasarathy Seshacharyulu, Surinder K. Batra, Mark A. Behlke, Sarah A. Zeiner, Ashley M. Jacobi, Yayoi Izu, Wallace B. Thoreson, Lisa D. Urness, Suzanne L. Mansour, Masato Ohtsuka, and Channabasavaiah B. Gurumurthy: Easi-CRISPR: A robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Genome Biol 18: 92, 2017

DOI: 10.1186/s13059-017-1220-4

3) Sei-ichiro Ohkura, Soichiro Usui, Shin-ichiro Takashima, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Yutaka Inagaki, Naotoshi Sugimoto, Teppei Kitano, Masayuki Takamura, Takashi Wada, Shuichi Kaneko, and Yoh Takuwa: Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6. PLoS ONE 12: e0182329, 2017
DOI: 10.1371/journal.pone.0182329

4) Wataru Ando, Hiroaki Yokomori, Akira Isomoto, Hiroyuki Tachibana, Nobuhiro Tsutsui, Yutaka Inagaki, Isao Okazaki, and Takako Komiyama Serum apelin-36 level is useful for early detection of liver fibrosis in nonalcoholic steatohepatitis patients. Kitasato Med J 47: 129-140, 2017

5) Takuya Komachi, Hideaki Sumiyoshi, Yutaka Inagaki, Shinji Takeoka, Yu Nagase, and Yosuke Okamura. Adhesive and robust multi-layered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model. J Biomed Mater Res Part B 105: 1747-1757, 2017
DOI:10.1002/jbm.b.33714

6) Hiroaki Yokomori, Masaya Oda, Wataru Ando, Yutaka Inagaki, and Isao Okazaki: Hepatic progenitor cell expansion in early-stage nonalcoholic steatohepatitis: evidence from immunohistochemistry and immunoelectron microscopy of matrix metalloproteinase-1. Med Mol Morphol 50: 238-242,2017
DOI: 10.1007/s00795-017-0162-y

7) Seiji Okada, Takeyuki Saito, Masamitsu Hara, Hiromi Kumamaru, Kazu Kobayakawa, Kazuya Yokota, Ken Kijima, Shingo Yoshizaki, Katsumi Harimaya, Yoshihiro Matsumoto, Kenichi Kawaguchi, Mitsumasa Hayashida, Yutaka Inagaki, Keiichiro Shiba, and Yasuharu Nakashima: Macrophage infiltration is a causative factor for ligamentum flavum hypertrophy through the activation of collagen production in fibroblasts. Am J Pathol 187: 2831-2840,2017
DOI: 10.1006/j.ajpath.2017.08.020

2016年

1) Tadashi Moro, Sachie Nakao, Hideaki Sumiyoshi, Takamasa Ishii, Masaki Miyazawa, Naoaki Ishii, Tadayuki Sato, Yumi Iida, Yoshinori Okada, Masayuki Tanaka, Hideki Hayashi, Satoshi Ueha, Kouji Matsushima, and Yutaka Inagaki: A combination of mitochondrial oxidative stress and excess fat/calorie intake accelerates steatohepatitis by enhancing hepatic CC chemokine production in mice. PLoS ONE 11: e0146592, 2016
doi:10.1371/journal.pone.0146592

2) Yusuke Matsuo, Fumitaka Mizoguchi, Tetsuya Saito, Kimito Kawahata, Satoshi Ueha, Kouji Matsushima, Yutaka Inagaki, Nobuyuki Miyasaka, and Hitoshi Kohsaka: Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis. Biochem Biophys Res Commun 470:504-509, 2016
doi:10.1016/j.bbrc.2016.01.121

3) Ah-Mee Park, Kyosuke Kanai, Tatsuki Itoh, Takao Sato, Tatsuya Tsukui, Yutaka Inagaki, Moises Selman, Kouji Matsushima, Osamu Yoshie:
Heat shock protein 27 plays a pivotal role in myofibroblast differentiation and in the development of bleomycin-induced pulmonary fibrosis. PLoS ONE 11:e0148998, 2016
doi:10.1371/journal.pone.0148998

4) Florian Rieder, Dominik Bettenworth, Jin Imai, and Yutaka Inagaki. Intestinal fibrosis and liver fibrosis –consequences of chronic inflammation or independent pathophysiology?" Inflamm Intest Dis 2016
DOI:10.1159/000445135

5) Kazuya Anzai, Hiromi Chikada, Kota Tsuruya, Kinuyo Ida, Tatehiro Kagawa, Yutaka Inagaki, Tesuya Mine, and Akihide Kamiya. Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture.Sci Rep 6: 28283, 2016
DOI:10.1038/srep28283 doi:10.1038/srep28283

6) Takayo Yanagawa, Kimitoshi Denda, Takuya Inatani, Toshiaki Fukushima, Toshiaki  Tanaka, Nobue Kumaki, Yutaka Inagaki, and Masayuki Komada. Deficiency of X-linked protein kinase Nrk during pregnancy triggers breast tumor in mice. Am J Pathol 186:2751-2760, 2016
DOI:10.1016/j.ajpath.2016.06.005

2015年

1) Akihide Kamiya and Yutaka Inagaki: Stem and progenitor cell systems in liver development and regeneration. Hepatol Res 45: 29-37, 2015

2) 稲垣　豊：肝線維化研究の進歩と治療の展望．日本肝臓学会50年のあゆみ, 日本肝臓学会編, 大村印刷, 東京, 2015, pp175-181.

3) Kota Tsuruya , Hiromi Chikada, Kinuyo Ida, Kazuya Anzai, Tatehiro Kagawa, Yutaka Inagaki, Tetsuya Mine, and Akihide Kamiya : A paracrine mechanism accelerating expansion of human induced pluripotent stem cell-derived hepatic progenitor-like cells. Stem Cells Dev 24: 1691-1702, 2015

4) Zhongzhi Wang, Masatoshi Jinnin, Yuki Kobayashi, Hideo Kudo, Kuniko Inoue, Wakana Nakayama, Noritoshi Honda, Katsunari Makino, Ikko Kajihara, Takamitsu Makino, Satoshi Fukushima, Yutaka Inagaki, and Hironobu Ihn: Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin. J Dermatol Sci 79: 268-278, 2015.

5) Shigeyuki Shichino, Jun Abe, Satoshi Ueha, Mikiya Otsuji, Tatsuya Tsukui, Mizuha Kosugi-Kanaya, Francis HW Shand, Shin-ichi Hashimoto, Hiroshi I. Suzuki, Teppei Morikawa, Yutaka Inagaki, and Kouji Matsushima: Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice. Am J Pathol 185: 2923-2938, 2015

6) Tatsuya Tsukui, Satoshi Ueha, Shigeyuki Shichino, Yutaka Inagaki, and Kouji Matsushima: Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis. Am J Pathol 185: 2939-2948, 2015

7) Jin Imai, Katsuto Hozumi, Hideaki Sumiyoshi, Masaki Yazawa, Ken-ichi Hirano, Jun Abe, Kiyoshi Higashi, Yutaka Inagaki, and Tetsuya Mine: Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis. Biochem Biophys Res Commun 468: 554-60, 2015

2014年

1) Hanako Yamaoka, Hideaki Sumiyoshi, Kiyoshi Higashi, Sachie Nakao, Kaori Minakawa, Kayo Sumida, Koichi Saito, Norihiro Ikoma, Tomotaka Mabuchi, Akira Ozawa, and Yutaka Inagaki: A novel small compound accelerates dermal wound healing by modifying infiltration, proliferation and migration of distinct cellular components in mice. J Dermatol Sci 74: 204-213, 2014

2) Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Zamira Hernandez-Nazara, Ana Rosa Rincon-Sanchez, Yutaka Inagaki, Marcos Rojkind, and M. Raj Lakshman: Mechanisms of action of acetaldehyde in the up regulation of the human α-2(I) collagen gene in hepatic stellate cells-key roles of Ski, SMAD3, SMAD4 and SMAD7. Am J Pathol 184: 1458-1467, 2014

3) Isao Okazaki, Takufumi Noro, Eigoro Yamanouchi, Hajime Kuroda, Masayuki Nakano, Hiroaki Yokomori, and Yutaka Inagaki: Fibrogenesis and Carcinogenesis in NASH: Role of MMPs and TIMPs. Cancers 6: 1220-1255, 2014

4) 稲垣　豊、住吉秀明：肝臓の線維化とその治療．日本内科学会雑誌 103: 2171-2175, 2014

5) Jun Abe, Shigeyuki Shichino, Satoshi Ueha, Shin-ichi Hashimoto, Michio Tomura, Yutaka Inagaki, Jens V. Stein, and Kouji Matsushima: Lymph node stromal cells negatively regulate antigen-specific CD4+ T cell responses. J Immunol 193:1636-1644, 2014

6) Miyako Tanaka, Kenji Ikeda, Takayoshi Suganami, Chikara Komiya, Kozue Ochi, Ibuki Shirakawa, Miho Hamaguchi, Satoshi Nishimura, Ichiro Manabe, Takahisa Matsuda, Kumi Kimura, Hiroshi Inoue, Yutaka Inagaki, Seiichiro Aoe, Sho Yamasaki, and Yoshihiro Ogawa: Macrophage-inducible C-type lectin underlies obesity- induced adipose tissue fibrosis. Nat Commun 5:4982, 2014

2013年

1) Tatsuya Tsukui, Satoshi Ueha, Jun Abe, Shin-ichi Hashimoto, Shigeyuki Shichino, Takeshi Shimaoka, Francis HW Shand, Yasuka Arakawa, Kenshiro Oshima, Masahira Hattori, Yutaka Inagaki, Michio Tomura, and Kouji Matsushima: Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis. Am J Pathol 183: 758-773, 2013

2) Xiaoran Li, Ying Bian, Yuri Takizawa, Tomio Hashimoto, Toshiyuki Ikoma, Junzo Tanaka, Naomi Kitamura, Yutaka Inagaki, Masayuki Komada, and Toshiaki Tanaka: ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression. Mol Cancer Res 11: 1437-1447, 2013

2012年

1) Yutaka Inagaki, Reiichi Higashiyama and Kiyoshi Higashi: Novel anti-fibrotic modalities for liver fibrosis: Molecular targeting and regenerative medicine in fibrosis therapy. J Gastroenterol Hepatol 27: 85-88, 2012

2) Yutaka Inagaki and Reiichi Higashiyama: Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis. Hepatol Res 42: 543-548, 2012

3) Isao Okazaki and Yutaka Inagaki: Novel strategies for hepatocellular carcinoma based on MMPs science. Anti-Cancer Agents Med Chem 12: 753-763, 2012

2011年

1) Reiichi Higashiyama, Sachie Nakao, Yayoi Shibusawa, Osamu Ishikawa, Tadashi Moro, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kaori Minakawa, Yasuhiko Tabata, George Bou-Gharios and Yutaka Inagaki: Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice. J Invest Dermatol 131: 529-536, 2011

2) Kiyoshi Higashi, Yoshitaka Tomigahara, Hiroaki Shiraki, Kaori Miyata, Toshiyuki Mikami, Toru Kimura, Tadashi Moro, Yutaka Inagaki, and Hideo Kaneko: A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. J Biol Chem 286: 4485-4492, 2011

2010年

1) Junichi Saito, Yasutada Imamura, Joji Itoh, Shigeo Matsuyama, Akie Maruta, Toshihiko Hayashi, Ataru Sato, Norihito Wada, Kazuo Kashiwazaki, Yutaka Inagaki, Tetsu Watanabe, Yuko Kitagawa and Isao Okazaki: ELISA measurement for urinary 3-hydroxyproline-containing-peptides and its preliminary application to healthy persons and cancer patients. Anticancer Res 30: 1007-1014, 2010

2009年

1) Reiichi Higashiyama, Tadashi Moro, Sachie Nakao, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kazuo Ikeda, Eijiro Adachi, George Bou-Gharios, Isao Okazaki, and Yutaka Inagaki: Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology 137: 1459-1466, 2009

2) Hitoshi Endo, Tetsu Watanabe, Yoshihiko Sugioka, Maki Niioka, Yutaka Inagaki, and Isao Okazaki: Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cell lines. Int J Oncology 35: 1237-1245, 2009

2008年

1) Yutaka Inagaki, Kiyoshi Higashi, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Tadashi Moro, Johbu Itoh, Toshiyuki Mikami, Toru Kimura, Goshi Shiota, Ichiro Kuwabara, and Isao Okazaki: Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7. Gastroenterology 134: 1180-1190, 2008

2) Tadashi Moro, Yoshihito Shimoyama, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Yoshihiko Sugioka, Hideo Inoue, Isao Okazaki, and Yutaka Inagaki: Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis. Life Sciences 83: 531-539, 2008

2007年

1) Reiichi Higashiyama, Yutaka Inagaki, Yun Yu Hong, Miwa Kushida, Sachie Nakao, Maki Niioka, Tetsu Watanabe, Hideyuki Okano, Yumi Matsuzaki, Goshi Shiota and Isao Okazaki: Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 45: 213-222, 2007

2) Kohji Kinoshita, Yuji Iimuro, Jiro Fujimoto, Yutaka Inagaki, Kazuhiko Namikawa, Hiroshi Kiyama, Yuji Nakajima, Kohji Otogawa, Norifumi Kawada, Scott L Friedman and Kazuo Ikeda: Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre-LoxP system to antagonise hepatic fibrosis. Gut 56: 396-404, 2007

3) Kohji Kinoshita, Yuji Iimuro, Kohji Otogawa, Shizuya Saika, Yutaka Inagaki, Yuji Nakajima, Norifumi Kawada, Scott L Friedman and Kazuo Ikeda: Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut 56: 706-714, 2007

4) Yutaka Inagaki, Reiichi Higashiyama and Isao Okazaki: Treatment Strategy for liver fibrosis through recruitment and differentiation of bone marrow stem/progenitor cells. Hepatol Res 37: 991-993, 2007

5) Yutaka Inagaki and Isao Okazaki: Emerging insights into transforming growth factor-β Smad signal in hepatic fibrogenesis. Gut 56: 284-292, 2007

2006年

1) Nobuhiro Izumi, Shinjiro Mizuguchi, Yutaka Inagaki, Shizuya Saika, Norifumi Kawada, Yuji Nakajima, Kiyotoshi Inoue, Shigefumi Suehiro, Scott L Friedman and Kazuo Ikeda: BMP-7 opposes TGFβ1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. Am J Physiol Lung Cellular and Molecular Physiology 290: L120-L126, 2006

2) Youko Komaki, Hiroyuki Furuya, Reiichi Higashiyama, Takaaki Kinoue, Shun Ito, Yutaka Inagaki, Tetsu Watanabe, Yasuhiko Honma, and Isao Okazaki. Detection of individual over-smoking using conventional laboratory tests. Tokai J Exp Clin Med 31: 17-28, 2006

2005年

1) Sonoko Chujo, Fumiaki Shirasaki, Shigeru Kawara, Yutaka Inagaki, Takuro Kinbara, Masaharu Takigawa, and Kazuhiko Takehara: Connective tissue growth factor causes persistent proα2(I) collagen gene expression induced by transforming growth factor-β in a mouse fibrosis model. J Cell Physiol 203: 447-456, 2005

2) Tomoaki Yoshino, Hideaki Sumiyoshi, Toshitaka Shin, Noritaka Matsuo, Yutaka Inagaki, Yoshifumi Ninomiya and Hidekatsu Yoshioka: Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human α1(III) collagen gene (COL3A1). Biochim Biophys Acta 1729: 94-104, 2005

3) Yutaka Inagaki, Miwa Kushida, Kiyoshi Higashi, Johbu Itoh, Reiichi Higashiyama, Yun Yu Hong, Norifumi Kawada, Kazuhiko Namikawa, Hiroshi Kiyama, George Bou-Gharios, Tetsu Watanabe, Isao Okazaki and Kazuo Ikeda: Cell type-specific intervention of TGF-β/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. Gastroenterology 129: 259-268, 2005

4) Gianluca Svegliati-Baroni, Yutaka Inagaki, Ana-Rosa Rincon-Sanchez, Cindy Else, Stefania Saccomanno, Antonio Benedetti, Francesco Ramirez and Marcos Rojkind: Early response of α2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-β-independent. Hepatology 42: 343-352, 2005

2004年

1) Yoshihiko Sugioka, Tetsu Watanabe, Yutaka Inagaki, Miwa Kushida, Maki Niioka, Hitoshi Endo, Reiichi Higashiyama and Isao Okazaki: c-JUN NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. Int J Cancer 109: 867-874, 2004

2003年

1) Kiyoshi Higashi, Yutaka Inagaki, Noriyuki Suzuki, Shinichi Mitsui, Alain Mauviel, Hideo Kaneko and Iwao Nakatsuka: Y-box binding protein YB-1 mediates transcriptional repression of humanα 2(I) collagen gene expression by interferon-γ. J Biol Chem 278: 5156-5162, 2003

2) Yutaka Inagaki, Tomoyuki Nemoto, Miwa Kushida, Yin Sheng, Kiyoshi Higashi, Kazuo Ikeda, Norifumi Kawada, Fumiaki Shirasaki, Kazuhiko Takehara, Kota Sugiyama, Mitsukiyo Fujii, Hiroshi Yamauchi, Atsuhito Nakao, Benoit de Crombrugghe, Tetsu Watanabe and Isao Okazaki: Interferon α down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology 38: 890-899, 2003

3) Kiyoshi Higashi, Yutaka Inagaki, Ko Fujimori, Atsuhito Nakao, Hideo Kaneko and Iwao Nakatsuka: Interferon-γ interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3. J Biol Chem 278: 43470-43479, 2003

4) Yutaka Kanamaru, Atsuhito Nakao, Yuichi Tanaka, Yutaka Inagaki, Hiroko Ushio, Isao Shirato, Satoshi Horikoshi, Ko Okumura, Hideoki Ogawa and Yasuhiko Tomino: Involvement of p300 in TGF-β/Smad-pathway-mediated α2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol 95: e36-e42, 2003

5) Yutaka Inagaki, Kiyoshi Higashi, Tomoyuki Nemoto, Miwa Kushida and Isao Okazaki: Treatment strategies for organ fibrosis based on regulation of collagen metabolism. Connective Tissue 35: 193-200, 2003

6) Yutaka Inagaki, Tomoyuki Nemoto, and Atsuhito Nakao: Transcriptional activation of type I collagen gene during hepatic fibrogenesis. In: Extracellular Matrix and the Liver-Approach to Gene Therapy, Okazaki I, Ninomiya Y, Friedman SL and Tanikawa K (Eds), Academic Press, New York, 2003, p.233-248.

2002年

1) 岡崎　勲，渡辺　哲，稲垣　豊：肝線維化研究の進歩．日本消化器病学会雑誌 99: 353-364, 2002

2) Yutaka Inagaki, Tomoyuki Nemoto, and Atsuhito Nakao: Transcriptional regulation of type I collagen gene expression by transforming growth factor-β/Smad signaling and its antagonistic factors. Connective Tissue 34: 139-146, 2002

2002年 （東海大学着任）以前の主要論文

1) Yutaka Inagaki, Sharada Truter and Francesco Ramirez: Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 269: 14828- 14834, 1994

2) Yutaka Inagaki, Sharada Truter, Maurizio DiLiberto, Shizuko Tanaka and Francesco Ramirez: Overlapping pathways mediate the opposing actions of tumor necrosis factor-β and transforming growth factor-β on α2(I) collagen gene transcription. J Biol Chem 270: 3353-3358, 1995

3) Yutaka Inagaki, Sharada Truter, Patricia Greenwel, Marcos Rojkind, Masashi Unoura, Kenichi Kobayashi and Francesco Ramirez: Regulation of the α2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology 22: 573-579, 1995

4) Patricia Greenwel, Yutaka Inagaki, Wei Hu, Martin Walsh and Francesco Ramirez: Sp1 is required for the early response of α2(I) collagen to transforming growth factor-β1. J Biol Chem 272: 19738-19745, 1997

5) Yutaka Inagaki, Sharada Truter, George Bou-Gharios, Lee Ann Garrett, Benoit de Crombrugghe, Tomoyuki Nemoto and Patricia Greenwel: Activation of proα2(I) collagen promoter during hepatic fibrogenesis in transgenic mice. Biochem Biophys Res Commun 250: 606-611, 1998

6) Wen Zhang, Jiongwen Ou, Yutaka Inagaki, Patricia Greenwel and Francesco Ramirez: Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor β1 stimulation of α2(I) collagen (COL1A2) transcription. J Biol Chem 275: 39237-39245, 2000

7) Yutaka Inagaki, Mizuko Mamura, Yutaka Kanamaru, Patricia Greenwel, Tomoyuki Nemoto, Kazuhiko Takehara, Peter ten Dijke and Atsuhito Nakao: Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 187: 117-123, 2001

8) Yutaka Inagaki, Tomoyuki Nemoto, Atsuhito Nakao, Peter ten Dijke, Kenichi Kobayashi, Kazuhiko Takehara and Patricia Greenwel: Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription. J Biol Chem 276: 16573-16579, 2001